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Article

Characterization of Protein Kinase ULK3 Regulation by Phosphorylation and Inhibition by Small Molecule SU6668.

Biochemistry - 18 Sept 2018

Kasak Lagle, Näks Mihkel, Eek Priit, Piirsoo Alla, Bhadoria Rohit, Starkov Pavel, Saarma Merilin, Kasvandik Sergo, Piirsoo Marko

Abstract excerpt

Serine/threonine protein kinase ULK3 is implicated in a variety of cellular processes, including autophagy, cell division, and execution of the Sonic hedgehog pathway. However, very little about how its biological activity could be controlled is known. This study focuses on unraveling biochemical insights into the mechanism of inhibition and activation of ULK3. We identify novel phosphorylation sites in ULK3 and...

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Source

Identifiers

PMID: 30096229
DOI: 10.1021/acs.biochem.8b00356

Genes

ULK3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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