Article

ERK2 MAP kinase regulates SUFU binding by multisite phosphorylation of GLI1

2021-12-23

Abstract excerpt

There is considerable evidence that crosstalk between the Hedgehog and MAPK signaling pathways occurs in several types of cancer, and contributes to the emergence of clinical resistance to Hedgehog pathway inhibitors. Here we show that MAP kinase-mediated phosphorylation weakens the binding of the GLI1 transcription factor to its negative regulator SUFU. ERK2 phosphorylates GLI1 on three evolutionarily-conserved t...

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Literature Corpus work: 61fd6cd8-c5e6-5f5a-b30b-48144553f15c
DOI: 10.1101/2021.12.22.473898

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