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Article

Structural basis of SUFU–GLI interaction in human Hedgehog signalling regulation

19 Nov 2013

Abstract excerpt

Hedgehog signalling plays a fundamental role in the control of metazoan development, cell proliferation and differentiation, as highlighted by the fact that its deregulation is associated with the development of many human tumours. SUFU is an essential intracellular negative regulator of mammalian Hedgehog signalling and acts by binding and modulating the activity of GLI transcription factors. Despite its central...

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PMID: 24311597
DOI: 10.1107/s0907444913028473

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