Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

doi:10.1016/j.semcdb.2014.05.003

Article

Context-dependent signal integration by the GLI code: The oncogenic load, pathways, modifiers and implications for cancer therapy

19 May 2014

Abstract excerpt

Canonical Hedgehog (HH) signaling leads to the regulation of the GLI code: the sum of all positive and negative functions of all GLI proteins. In humans, the three GLI factors encode context-dependent activities with GLI1 being mostly an activator and GLI3 often a repressor. Modulation of GLI activity occurs at multiple levels, including by co-factors and by direct modification of GLI structure. Surprisingly, the...

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