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Article

Integrative analysis of eQTL and GWAS summary statistics reveals transcriptomic alteration in Alzheimer brains.

BMC medical genomics - 23 Apr 2022

Varathan Pradeep, Gorijala Priyanka, Jacobson Tanner, Chasioti Danai, Nho Kwangsik, Risacher Shannon L, Saykin Andrew J, Yan Jingwen

Abstract excerpt

BACKGROUND: Large-scale genome-wide association studies have successfully identified many genetic variants significantly associated with Alzheimer's disease (AD), such as rs429358, rs11038106, rs723804, rs13591776, and more. The next key step is to understand the function of these SNPs and the downstream biology through which they exert the effect on the development of AD. However, this remains a challenging task...

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Source

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Identifiers

PMID: 35461270
DOI: 10.1186/s12920-022-01245-5
PMCID: PMC9035239

Genes

TOMM40
TP53

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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