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Proteome-wide association studies using summary pQTL data of three tissues identified 30 risk genes of Alzheimer’s disease dementia

2024-03-30

Abstract excerpt

<h4>Background</h4> Proteome-wide association study (PWAS) integrating proteomic data with genome-wide association study (GWAS) summary data is a powerful tool for studying Alzheimer’s disease (AD) dementia. Existing PWAS analyses of AD often rely on the availability of individual-level proteomic and genetic data of a reference panel. Leveraging summary protein quantitative trait loci (pQTL) reference data of mult...

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Literature Corpus work: 837634cf-6632-5be6-b48e-18fb75343dba
DOI: 10.1101/2024.03.28.24305044

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