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An analysis of genetically regulated gene expression across multiple tissues implicates novel gene candidates in Alzheimer's disease.

Alzheimer's research & therapy - 16 Apr 2020

Gerring Zachary F, Lupton Michelle K, Edey Daniel, Gamazon Eric R, Derks Eske M

Abstract excerpt

INTRODUCTION: Genome-wide association studies (GWAS) have successfully identified multiple independent genetic loci that harbour variants associated with Alzheimer's disease, but the exact causal genes and biological pathways are largely unknown. METHODS: To prioritise likely causal genes associated with Alzheimer's disease, we used S-PrediXcan to integrate expression quantitative trait loci (eQTL) from the...

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Identifiers

PMID: 32299494
DOI: 10.1186/s13195-020-00611-8
PMCID: PMC7164172

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