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Identification of Alzheimer's disease susceptibility genes by integrating eight human brain single-cell transcriptomes with genome-wide association studies.

Journal of neurochemistry - 1 Jan 2025

He Yijie, Zhu Ping, Gao Shan, Wu Shiyang, Li Xuan, Huang Chen, Chen Yan, Liu Guiyou

Abstract excerpt

To date, several studies have integrated genome-wide association studies (GWAS) and expression quantitative trait loci (eQTL) data from bulk tissues to identify novel Alzheimer's disease (AD) genetic variants and susceptibility genes. However, there is highly cell-type-specific nature in different bulk eQTL data. Until now, eQTL data from different brain single cells have been reported. Therefore, integrating...

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PMID: 39655660
DOI: 10.1111/jnc.16276

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