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Article

Integrative analysis of summary data from GWAS and eQTL studies implicates genes differentially expressed in Alzheimer's disease.

BMC genomics - 2 Jun 2022

Lee Brian, Yao Xiaohui, Shen Li

Abstract excerpt

BACKGROUND: Although genome-wide association studies (GWAS) have successfully located various genetic variants susceptible to Alzheimer's Disease (AD), it is still unclear how specific variants interact with genes and tissues to elucidate pathologies associated with AD. Summary-data-based Mendelian Randomization (SMR) addresses this problem through an instrumental variable approach that integrates data from...

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Identifiers

PMID: 35655140
DOI: 10.1186/s12864-022-08584-8
PMCID: PMC9161451

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