Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Identification of causally linked blood biomarkers for Alzheimer's disease via reverse transcriptome-wide Mendelian randomization.

Journal of Alzheimer's disease : JAD - 1 Apr 2026

Li Zimo, Wang Dong, Xia Fei, Liu Yuchen, Liu Yunyi

Abstract excerpt

BackgroundAlzheimer's disease (AD) is a progressive neurodegenerative disorder with poorly understood molecular mechanisms and limited early detection biomarkers.ObjectiveTo identify genes causally associated with AD risk using reverse transcriptome-wide Mendelian randomization (revTWMR) and bulk RNA-sequencing (RNA-seq).MethodsWe analyzed publicly available RNA-seq data from peripheral blood samples of patients...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer Disease
Share to Biomarkers

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Gene Expression Profiling

Share to Genetic Predisposition to Disease

Share to Genome-Wide Association Study

Share to Mendelian Randomization Analysis

Share to Quantitative Trait Loci

Share to Transcriptome

Source

Identifiers

PMID: 41789865
DOI: 10.1177/13872877261422501

Genes

CD19
CMTM6
PSMA6

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 1 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Identification of causally linked blood biomarkers for Alzheimer's disease via reverse transcriptome-wide Mendelian randomization.PMID 41789865Read ↗

Exploring biomarkers of Alzheimer's disease based on multi-omics and Mendelian randomisation analysis.Semantic proximity Read ↗

Mendelian randomization and transcriptomic analysis reveal an inverse causal relationship between Alzheimer's disease and cancer.Semantic proximity Read ↗

Functional Genetic Biomarkers of Alzheimer’s Disease and Gene Expression from Peripheral BloodSemantic proximity Read ↗

Biomarker identification for Alzheimer's disease through integration of comprehensive Mendelian randomization and proteomics data.Semantic proximity Read ↗

Deep Post-GWAS Analysis Identifies Potential Risk Genes and Causal Variants for Alzheimer’s Disease, Providing New Insights Into Its Disease MechanismsSemantic proximity Read ↗

Integrative analysis of single-nucleus RNA sequencing and Mendelian randomization to explore novel risk genes for Alzheimer's disease.Semantic proximity Read ↗

Genome-wide association analysis of dementia and its clinical endophenotypes reveal novel loci associated with Alzheimer’s disease and three causality networks of AD: the GR@ACE projectSemantic proximity Read ↗

Deep Post-GWAS Analysis Identifies Potential Risk Genes and Causal Variants for Alzheimer’s Disease, Providing New Insights Into Its Disease MechanismsSemantic proximity Read ↗

Brain and Blood Transcriptome-Wide Association Studies Identify Five Novel Genes Associated with Alzheimer’s DiseaseSemantic proximity Read ↗

Brain and blood transcriptome-wide association studies identify five novel genes associated with Alzheimer's disease.Semantic proximity Read ↗

Summary-data-based Mendelian Randomization Analysis Identifies Nominal Evidence for Association of N6-Methyladenosine Genetic Variation with Alzheimer's Disease.Semantic proximity Read ↗

Exploratory Single-Cell RNA Sequencing of Peripheral Blood Identifies Candidate Signatures Associated with Alzheimer’s DiseaseSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.