Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Dormant state of quiescent neural stem cells links Shank3 mutation to autism development.

Molecular psychiatry - 1 Jun 2022

Kim Hongwon, Cho Byounggook, Park Hanseul, Kim Junyeop, Kim Siyoung, Shin Jaein, Lengner Christopher J, Won Kyoung-Jae, Kim Jongpil

Abstract excerpt

Autism spectrum disorders (ASDs) are common neurodevelopmental disorders characterized by deficits in social interactions and communication, restricted interests, and repetitive behaviors. Despite extensive study, the molecular targets that control ASD development remain largely unclear. Here, we report that the dormancy of quiescent neural stem cells (qNSCs) is a therapeutic target for controlling the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Autism Spectrum Disorder
Share to Autistic Disorder

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

Share to Disease Models, Animal

Share to Microfilament Proteins

Share to Mutation

Share to Nerve Tissue Proteins

Share to Neural Stem Cells

Source

Identifiers

PMID: 35444258
DOI: 10.1038/s41380-022-01563-1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Dormant state of quiescent neural stem cells links Shank3 mutation to autism development.PMID 35444258Read ↗

Comparison of SHANK3 deficiency in animal models: phenotypes, treatment strategies, and translational implications.Semantic proximity Read ↗

Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stabilitySemantic proximity Read ↗

Transcriptional Determinism and Stochasticity Contribute to the Complexity of Autism Associated <i>SHANK</i> Family GenesSemantic proximity Read ↗

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development.Semantic proximity Read ↗

Shank3 modulates sleep and expression of circadian transcription factorsSemantic proximity Read ↗

Shank3 Modulates Sleep and Expression of Circadian Transcription FactorsSemantic proximity Read ↗

Overcoming the effect of ASH1L haploinsufficiency on stem cells amenability to genome editing and differentiation into the neuronal lineage – a technical reportSemantic proximity Read ↗

Progressive changes in hippocampal stem cell properties ensure lifelong neurogenesisSemantic proximity Read ↗

Single-Cell Transcriptomics Supports a Role of CHD8 in Autism.Semantic proximity Read ↗

Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repressionSemantic proximity Read ↗

Chromatin regulator <i>Kdm6b</i> is required for the establishment and maintenance of neural stem cells in mouse hippocampusSemantic proximity Read ↗

Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.