Article

Autism-associated Shank3 is essential for homeostatic plasticity and neuronal circuit stability

2018-07-09

Abstract excerpt

<h4>Summary</h4> Mutations in Shank3 are strongly associated with autism spectrum disorders and circuit disfunction, but a unified view of how Shank3 loss disrupts circuit function and excitability is lacking. Stabilizing, homeostatic forms of synaptic and intrinsic plasticity are critical for preventing circuit hyper- or hypo-excitability, leading us to ask whether Shank3 loss perturbs circuits by disrupting hom...

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Literature Corpus work: 07ae96cf-2e81-5572-adcc-0b74456686a6
DOI: 10.1101/365445

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