Article

Hierarchical regulation of cerebellar neurogenesis by Sin3A-mediated gene repression

2025-10-17

Abstract excerpt

Cerebellar granule cells (GCs) are critical for motor and cognitive functions. Lineage tracing studies have identified a hierarchical developmental progression of GC neurogenesis, transitioning from Sox2+ stem-like cells to Atoh1+ rapidly proliferating granule cell precursors (GCPs), and ultimately to NeuN+ mature GCs. However, the molecular mechanisms governing these transitions remain poorly understood. In this...

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Literature Corpus work: d0e1b37b-0a41-58be-845d-ec10648f7f51
DOI: 10.1101/2025.10.17.683101

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