Article

Overcoming the effect of ASH1L haploinsufficiency on stem cells amenability to genome editing and differentiation into the neuronal lineage – a technical report

2021-09-28

Abstract excerpt

<h4>ABSTRACT</h4> Genome editing and neuronal differentiation protocols have proliferated in the last decade. Mutations in genes that control pluripotency could lead to a potential obstacle with regards to the survival and differentiation potential of the genome-edited cell lines. Here we describe a protocol for the generation, and differentiation, of cell lines containing CRISPR/Cas9 induced mutations in the his...

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Literature Corpus work: 8c9b7c43-8679-5b11-a238-d87d9d5d4123
DOI: 10.1101/2021.09.27.461943

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