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Article

Human Pluripotent Stem Cell-derived Cortical Neurons for High Throughput Medication Screening in Autism: A Proof of Concept Study in SHANK3 Haploinsufficiency Syndrome.

EBioMedicine - 1 Jul 2016

Darville Hélène, Poulet Aurélie, Rodet-Amsellem Frédérique, Chatrousse Laure, Pernelle Julie, Boissart Claire, Héron Delphine, Nava Caroline, Perrier Anselme, Jarrige Margot, Cogé Francis, Millan Mark J, Bourgeron Thomas, Peschanski Marc, Delorme Richard, Benchoua Alexandra

Abstract excerpt

Autism spectrum disorders affect millions of individuals worldwide, but their heterogeneity complicates therapeutic intervention that is essentially symptomatic. A versatile yet relevant model to rationally screen among hundreds of therapeutic options would help improving clinical practice. Here we investigated whether neurons differentiated from pluripotent stem cells can provide such a tool using SHANK3...

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Identifiers

PMID: 27333044
DOI: 10.1016/j.ebiom.2016.05.032
PMCID: PMC4972535

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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