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Article

Single-Cell Transcriptomics Supports a Role of CHD8 in Autism.

International journal of molecular sciences - 23 Mar 2021

Hoffmann Anke, Spengler Dietmar

Abstract excerpt

Chromodomain helicase domain 8 (CHD8) is one of the most frequently mutated and most penetrant genes in the autism spectrum disorder (ASD). Individuals with CHD8 mutations show leading symptoms of autism, macrocephaly, and facial dysmorphisms. The molecular and cellular mechanisms underpinning the early onset and development of these symptoms are still poorly understood and prevent timely and more efficient...

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Identifiers

PMID: 33806835
DOI: 10.3390/ijms22063261
PMCID: PMC8004931

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Single-Cell Transcriptomics Supports a Role of CHD8 in Autism.PMID 33806835Read ↗

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