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Article

Stem cell-derived neurons from autistic individuals with SHANK3 mutation show morphogenetic abnormalities during early development.

Molecular psychiatry - 1 Mar 2018

Kathuria A, Nowosiad P, Jagasia R, Aigner S, Taylor R D, Andreae L C, Gatford N J F, Lucchesi W, Srivastava D P, Price J

Abstract excerpt

Shank3 is a structural protein found predominantly at the postsynaptic density. Mutations in the SHANK3 gene have been associated with risk for autism spectrum disorder (ASD). We generated induced pluripotent stem cells (iPSCs) from control individuals and from human donors with ASD carrying microdeletions of SHANK3. In addition, we used Zinc finger nucleases to generate isogenic SHANK3 knockout human embryonic...

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Identifiers

PMID: 28948968
DOI: 10.1038/mp.2017.185
PMCID: PMC5822449

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 6 Sept 2026. Manifest publication-graph-cohort-2026-09-06.1.

Source receipt: pubmed, retrieved 6 Sept 2026.

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