Article

Progressive changes in hippocampal stem cell properties ensure lifelong neurogenesis

2020-03-12

Abstract excerpt

<h4>SUMMARY</h4> Neural stem cell numbers fall rapidly in the hippocampus of juvenile mice but stabilise during adulthood, ensuring lifelong hippocampal neurogenesis. We show that this reduction in stem cell depletion rate is the result of multiple coordinated changes in stem cell behaviour. In particular, while active neural stem cells divide only once or twice before differentiating rapidly in juveniles, they i...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: f2f4452c-33ed-524b-be95-008ac038f56b
DOI: 10.1101/2020.03.12.987107

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Progressive changes in hippocampal stem cell properties ensure lifelong neurogenesisDOI 10.1101/2020.03.12.987107Read

A Human Hippocampal Organoid Model with Sustained Neural Stem Cells Reveals State Shifts Under Glucocorticoid StressSemantic proximity Read

Deciphering molecular heterogeneity and dynamics of human hippocampal neural stem cells at different ages and injury statesSemantic proximity Read

Quiescence Entry, Maintenance, and Exit in Adult Stem CellsSemantic proximity Read

High resolution mouse subventricular zone stem cell niche transcriptome reveals features of lineage, anatomy, and agingSemantic proximity Read

Decoding the activated stem cell phenotype of the neonatally maturing pituitary.Semantic proximity Read

Alterations in neural stem cell quiescence and activation in the 3xTG-AD model of Alzheimer’s DiseaseSemantic proximity Read

Shared molecular regulation of quiescence in neural and glioma stem cells reveals therapeutic vulnerabilitiesSemantic proximity Read

A roadmap to human hippocampal neurogenesis in adulthood, aging and AD.Semantic proximity Read

Stem cell plasticity--building the brain of our dreams.Semantic proximity Read

Spatial transcriptomic analysis of adult hippocampal neurogenesis in the human brainSemantic proximity Read

Isolation of postnatal human neural stem cellsSemantic proximity Read

Neurogenesis in primates versus rodents and the value of non-human primate modelsSemantic proximity Read