Article

Transcriptional Determinism and Stochasticity Contribute to the Complexity of Autism Associated <i>SHANK</i> Family Genes

2024-03-19

Abstract excerpt

Precision of transcription is critical because transcriptional dysregulation is disease causing. Traditional methods of transcriptional profiling are inadequate to elucidate the full spectrum of the transcriptome, particularly for longer and less abundant mRNAs. SHANK3 is one of the most common autism causative genes. Twenty-four Shank3 mutant animal lines have been developed for autism modeling. However, their...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: ba1038b6-59dd-531a-96cc-6be18eb74ab0
DOI: 10.1101/2024.03.18.585480

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Transcriptional Determinism and Stochasticity Contribute to the Complexity of Autism Associated <i>SHANK</i> Family GenesDOI 10.1101/2024.03.18.585480Read

Analysis of a purported SHANK3 mutation in a boy with autism: clinical impact of rare variant research in neurodevelopmental disabilities.Semantic proximity Read

Meta-analysis of SHANK Mutations in Autism Spectrum Disorders: a gradient of severity in cognitive impairments.Semantic proximity Read

Long-read sequencing reveals the RNA isoform repertoire of neuropsychiatric risk genes in human brainSemantic proximity Read

Long-read proteogenomic atlas of human neuronal differentiation reveals isoform diversity informing neurodevelopmental risk mechanismsSemantic proximity Read

Illuminating hidden genetic architecture in autism.Semantic proximity Read

Truncating variants in the SHANK1 gene are associated with a spectrum of neurodevelopmental disorders.Semantic proximity Read

Whole genome sequencing reveals a de novo SHANK3 mutation in familial autism spectrum disorder.Semantic proximity Read

SHANK genes in autism: Defining therapeutic targets.Semantic proximity Read

Decomposing the genetic risk of autism spectrum disorder into discrete molecular subtypes underlie clinical heterogeneity based on transcriptome profile.Semantic proximity Read

Contribution of SHANK3 mutations to autism spectrum disorder.Semantic proximity Read

Shank3 Modulates Sleep and Expression of Circadian Transcription FactorsSemantic proximity Read

Protein-truncating variants and deletions of SHANK2 are associated with autism spectrum disorder and other neurodevelopmental concernsSemantic proximity Read