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Article

A variant in PPP4R3A protects against alzheimer-related metabolic decline.

Annals of neurology - 1 Dec 2017

Christopher Leigh, Napolioni Valerio, Khan Raiyan R, Han Summer S, Greicius Michael D

Abstract excerpt

OBJECTIVES: A reduction in glucose metabolism in the posterior cingulate cortex (PCC) predicts conversion to Alzheimer's disease (AD) and tracks disease progression, signifying its importance in AD. We aimed to use decline in PCC glucose metabolism as a proxy for the development and progression of AD to discover common genetic variants associated with disease vulnerability. METHODS: We performed a genome-wide...

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Identifiers

PMID: 29130521
DOI: 10.1002/ana.25094
PMCID: PMC5752155

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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