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Article

Mini-review: Role of the PI3K/Akt pathway and tyrosine phosphatases in Alzheimer's disease susceptibility.

Annals of human genetics - 1 Jan 2021

Curtis David, Bandyopadhyay Sreejan

Abstract excerpt

A variety of findings from in vitro experiments and animal models support the hypothesis that one contribution to pathogenesis in Alzheimer's disease (AD) is enhanced phosphorylation of tau protein, which may be triggered by amyloid β (Aβ) and mediated by impaired activity of the PI3K/Akt signaling pathway. A number of tyrosine phosphatases act to reduce PI3K/Akt activity, and inhibition of tyrosine phosphatases...

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PMID: 33258115
DOI: 10.1111/ahg.12410

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026.

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