Article

An Alzheimer’s disease-associated common regulatory variant in a PTK2B intron alters microglial function

2023-11-06

Abstract excerpt

<h4>Summary</h4> Genome-wide association studies (GWAS) are revealing an ever-growing number of genetic associations with disease, but identifying and functionally validating the causal variants underlying these associations is very challenging and has only been done for a vanishingly small number of variants. Here we validate a single nucleotide polymorphism (SNP) associated with an increased risk of Alzheimer’s...

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Literature Corpus work: 763e0d83-2485-54d1-8dee-68bc92c1ea8f
DOI: 10.1101/2023.11.04.565613

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