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Complement C7is a novel risk gene for Alzheimer's disease in Han Chinese

3 Nov 2018

Abstract excerpt

Abstract Alzheimer's disease is the most common neurodegenerative disease, and has a high level of genetic heritability and population heterogeneity. In this study, we performed the whole-exome sequencing of Han Chinese patients with familial and/or early-onset Alzheimer's disease, followed by independent validation, imaging analysis and function characterization. We identified an exome-wide significant rare...

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PMID: 31032141
DOI: 10.1093/nsr/nwy127

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