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<i>APOE3</i> Christchurch modulates tau phosphorylation and β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer’s cases

2023-01-13

Abstract excerpt

Alzheimer’s disease (AD) is the most common cause of dementia among older adults. APOE3 Christchurch (R136S, APOE3Ch ) variant homozygosity was reported in an individual with extreme resistance to autosomal dominant AD due to the PSEN1 E280A mutation. This subject had a delayed clinical age at onset and resistance to tauopathy and neurodegeneration despite extremely high amyloid plaque burden. We established in...

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Literature Corpus work
da469bed-44b5-57a5-8662-8aaa9c6ddb62
DOI
10.1101/2023.01.11.523290
Open publication

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<i>APOE3</i> Christchurch modulates tau phosphorylation and β-catenin/Wnt/Cadherin signaling in induced pluripotent stem cell-derived cerebral organoids from Alzheimer’s casesDOI 10.1101/2023.01.11.523290
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