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An updated Alzheimer hypothesis: Complement C3 and risk of Alzheimer‘s disease—A cohort study of 95,442 individuals

19 Sept 2018

Abstract excerpt

INTRODUCTION: We tested the hypothesis that low plasma complement C3 is observationally and genetically associated with high risk of Alzheimer's disease (AD). METHODS: We studied 95,442 individuals enrolled in the Copenhagen General Population Study. In genetic analyses, we further included 8367 individuals from the Copenhagen City Heart Study. In the two studies, 1189 and 35 developed AD during median 8 years...

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PMID: 30243924
DOI: 10.1016/j.jalz.2018.07.223

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