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Article

Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Mar 2022

Hutchinson Anne P, Yin Ping, Neale Ilona, Coon John S, Kujawa Stacy A, Liu Shimeng, Bulun Serdar E

Abstract excerpt

Uterine leiomyomas (fibroids) are common benign tumors in women. The tryptophan metabolism through the kynurenine pathway plays important roles in tumorigenesis in general. Leiomyomas expressing mutated mediator complex subunit 12 (mut-MED12) were reported to contain significantly decreased tryptophan levels; the underlying mechanism and the role of the tryptophan metabolism-kynurenine pathway in leiomyoma...

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Topics

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Share to Gene Expression Regulation, Neoplastic
Share to MED12 gene

Methodology Data sources Editorial policy Privacy Delete account & data About Contact Helena Bioinformatics

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Source

Open in PubMed Open full text

Identifiers

PMID: 35064560
DOI: 10.1007/s43032-022-00852-y
PMCID: PMC8863695

Genes

MED12
TDO2
IDO1
IDO2

Variants

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

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Tryptophan 2,3-Dioxygenase-2 in Uterine Leiomyoma: Dysregulation by MED12 Mutation Status.PMID 35064560Read ↗

MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.Semantic proximity Read ↗

Tryptophan catabolism is dysregulated in leiomyomas.Semantic proximity Read ↗

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MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Semantic proximity Read ↗

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