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Article

Frequency of MED12 Mutation in Relation to Tumor and Patient's Clinical Characteristics: a Meta-analysis.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2022

He Chao, Nelson William, Li Hui, Xu Ya-Dong, Dai Xue-Jiao, Wang Ying-Xiong, Ding Yu-Bin, Li Yan-Ping, Li Tian

Abstract excerpt

Mediator complex subunit 12 (MED12) is the most frequently mutated gene in uterine leiomyomas (ULs)-with a frequency of up to 85%-suggesting that it plays key roles in the pathogenesis of ULs. However, there is no established relationship between genetic alteration and other risk factors of UL pathogenesis such as the patient's age, weight, and race. In this meta-analysis, we established an association between...

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PMID: 33569750
DOI: 10.1007/s43032-021-00473-x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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