Article
MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.
Science (New York, N.Y.) - 14 Oct 2011
Mäkinen Netta, Mehine Miika, Tolvanen Jaana, Kaasinen Eevi, Li Yilong, Lehtonen Heli J, Gentile Massimiliano, Yan Jian, Enge Martin, Taipale Minna, Aavikko Mervi, Katainen Riku, Virolainen Elina, Böhling Tom, Koski Taru A, Launonen Virpi, Sjöberg Jari, Taipale Jussi, Vahteristo Pia, Aaltonen Lauri A
Abstract excerpt
Uterine leiomyomas, or fibroids, are benign tumors that affect millions of women worldwide and that can cause considerable morbidity. To study the genetic basis of this tumor type, we examined 18 uterine leiomyomas derived from 17 different patients by exome sequencing and identified tumor-specific mutations in the mediator complex subunit 12 (MED12) gene in 10. Through analysis of 207 additional tumors, we...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.