Article
Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas.
Scientific reports - 21 Apr 2017
Heinonen Hanna-Riikka, Pasanen Annukka, Heikinheimo Oskari, Tanskanen Tomas, Palin Kimmo, Tolvanen Jaana, Vahteristo Pia, Sjöberg Jari, Pitkänen Esa, Bützow Ralf, Mäkinen Netta, Aaltonen Lauri A
Abstract excerpt
Up to 86% of uterine leiomyomas harbour somatic mutations in mediator complex subunit 12 (MED12). These mutations have been associated with conventional histology, smaller tumour size, and larger number of tumours within the uterus. Prior studies, with limited sample sizes, have failed to detect associations between other clinical features and MED12 mutations. Here, we prospectively collected 763 uterine...
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