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Article

Vitamin D as an effective treatment in human uterine leiomyomas independent of mediator complex subunit 12 mutation.

Fertility and sterility - 1 Feb 2021

Corachán Ana, Trejo María Gabriela, Carbajo-García María Cristina, Monleón Javier, Escrig Julia, Faus Amparo, Pellicer Antonio, Cervelló Irene, Ferrero Hortensia

Abstract excerpt

OBJECTIVE: To study whether vitamin D (VitD) inhibits cell proliferation and Wnt/β-catenin and transforming growth factor-β (TGFβ) signaling pathways in uterine leiomyomas independent of mediator complex subunit 12 (MED12) mutation status. DESIGN: Prospective study comparing leiomyoma vs. myometrial tissues and human uterine leiomyoma primary (HULP) cells treated with or without VitD and analyzed by MED12...

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Identifiers

PMID: 33036796
DOI: 10.1016/j.fertnstert.2020.07.049

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