Article
UTERINE FIBROIDS.
Physiological reviews - 1 Oct 2025
Bulun Serdar E, Yin Ping, Wei JianJun, Zuberi Azna, Iizuka Takashi, Suzuki Takuma, Saini Priyanka, Goad Jyoti, Parker J Brandon, Adli Mazhar, Boyer Thomas, Chakravarti Debabrata, Rajkovic Aleksandar
Abstract excerpt
Uterine fibroids (leiomyomas), the most common tumors in women and those assigned female at birth, originate from myometrial smooth muscle cells and cause heavy menstrual bleeding, anemia, pelvic discomfort, pregnancy loss, and obstruction of labor in approximately a quarter of reproductive-age women. During each ovulatory cycle, the myometrium responds to the ovarian steroids, estradiol, and progesterone, via...
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