Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.

PloS one - 1 Jan 2012

McGuire Megan M, Yatsenko Alexander, Hoffner Lori, Jones Mirka, Surti Urvashi, Rajkovic Aleksandar

Abstract excerpt

Uterine leiomyomas (uterine fibroids) arise from smooth muscle tissue in the majority of women by age 45. It is common for these clonal tumors to develop from multiple locations within the uterus, leading to a variety of symptoms such as pelvic pain, abnormal uterine bleeding, and infertility. We...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA, Complementary
Share to Exome
Share to Genetic Association Studies

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leiomyomatosis

Share to Mediator Complex

Share to North America

Share to Sequence Analysis, DNA

Share to Uterine Neoplasms

Source

Open in PubMed Open full text

Identifiers

PMID: 22428002
DOI: 10.1371/journal.pone.0033251
PMCID: PMC3299761

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 4 Sept 2026. Prepared record publication-22428002-2026-09-04.2. Manifest publication-graph-cohort-2026-09-04.2.

Source receipt: PubMed via Helena Literature Corpus, retrieved 4 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.PMID 22428002Read ↗

Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas.Semantic proximity Read ↗

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Semantic proximity Read ↗

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.Semantic proximity Read ↗

Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays.Semantic proximity Read ↗

The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.Semantic proximity Read ↗

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.Semantic proximity Read ↗

MED12 mutation frequency in unselected sporadic uterine leiomyomas.Semantic proximity Read ↗

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.Semantic proximity Read ↗

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.Semantic proximity Read ↗

Genomic Insights into Uterine Leiomyomas: A Systematic Review of Whole-Genome and Whole- Exome Sequencing StudiesSemantic proximity Read ↗

3'RNA and whole-genome sequencing of archival uterine leiomyomas reveal a tumor subtype with chromosomal rearrangements affecting either HMGA2, HMGA1, or PLAG1.Semantic proximity Read ↗

Detection of exon2-MED12 mutations in uterine leiomyomas from Syrian patients.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.