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Article

Detection of exon2-MED12 mutations in uterine leiomyomas from Syrian patients.

Scientific reports - 2 Jan 2025

Albitar Lina, Al-Chatty Eyad, Ahmad Fariz

Abstract excerpt

Uterine leiomyomas (uLMs) are the most prevalent benign tumors of the female reproductive system. MED12 is one of the mediator complex subunits that has been implicated in uLMs pathogenesis. Somatic mutations in exon2-MED12 have been found in ~ 70% of uLMs. In this study, we investigated the status of exon2-MED12 in uLMs from Syrian patients. Sixteen leiomyomas from nine patients were assessed. Genomic DNA was...

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Identifiers

PMID: 39747270
DOI: 10.1038/s41598-024-84439-4
PMCID: PMC11697450

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