Article
Integrated data analysis reveals uterine leiomyoma subtypes with distinct driver pathways and biomarkers.
Proceedings of the National Academy of Sciences of the United States of America - 2 Feb 2016
Mehine Miika, Kaasinen Eevi, Heinonen Hanna-Riikka, Mäkinen Netta, Kämpjärvi Kati, Sarvilinna Nanna, Aavikko Mervi, Vähärautio Anna, Pasanen Annukka, Bützow Ralf, Heikinheimo Oskari, Sjöberg Jari, Pitkänen Esa, Vahteristo Pia, Aaltonen Lauri A
Abstract excerpt
Uterine leiomyomas are common benign smooth muscle tumors that impose a major burden on women's health. Recent sequencing studies have revealed recurrent and mutually exclusive mutations in leiomyomas, suggesting the involvement of molecularly distinct pathways. In this study, we explored transcriptional differences among leiomyomas harboring different genetic drivers, including high mobility group AT-hook 2...
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