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Article

Tryptophan catabolism is dysregulated in leiomyomas.

Fertility and sterility - 1 Oct 2021

Chuang Tsai-Der, Quintanilla Derek, Boos Drake, Khorram Omid

Abstract excerpt

OBJECTIVE: To determine the expression and functional roles of indoleamine 2,3-dioxygenase 1 (IDO1) and tryptophan 2,3-dioxygenase (TDO2) in leiomyoma. DESIGN: Experimental study. SETTING: Academic research laboratory. PATIENT(S): Women undergoing hysterectomy for leiomyoma. INTERVENTION(S): Blockade of IDO1 and TDO2. MAIN OUTCOME MEASURE(S): Expression of IDO1 and TDO2 in leiomyoma and the effects of their...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 34116832
DOI: 10.1016/j.fertnstert.2021.05.081
PMCID: PMC8787760

Genes

TDO2
IDO1
COL1A1
COL3A1
MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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