Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas.

International journal of cancer - 15 Feb 2014

Mäkinen Netta, Vahteristo Pia, Bützow Ralf, Sjöberg Jari, Aaltonen Lauri A

Abstract excerpt

Uterine leiomyomas are extremely common tumors originating from the smooth muscle cells of myometrium. We recently reported recurrent somatic mutations in mediator complex subunit 12 (MED12) in the majority of these lesions, and analyzed chromosomal abnormalities in leiomyomas by whole-genome sequencing. The aim of our study was to examine in detail uterine leiomyoma exomes, to search for driver mutations in...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to DNA Mutational Analysis
Share to Exome
Share to High-Throughput Nucleotide Sequencing

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Leiomyoma

Share to Loss of Heterozygosity

Share to Mediator Complex

Share to Neoplasm Recurrence, Local

Share to Uterine Neoplasms

Source

Identifiers

PMID: 23913526
DOI: 10.1002/ijc.28410

Genes

MED12

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 2 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Exomic landscape of MED12 mutation-negative and -positive uterine leiomyomas.PMID 23913526Read ↗

Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.Semantic proximity Read ↗

Multiple clinical characteristics separate MED12-mutation-positive and -negative uterine leiomyomas.Semantic proximity Read ↗

MED12 mutation frequency in unselected sporadic uterine leiomyomas.Semantic proximity Read ↗

MED12, the mediator complex subunit 12 gene, is mutated at high frequency in uterine leiomyomas.Semantic proximity Read ↗

Highly heterogeneous genomic landscape of uterine leiomyomas by whole exome sequencing and genome-wide arrays.Semantic proximity Read ↗

The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.Semantic proximity Read ↗

Somatic MED12 mutations in uterine leiomyosarcoma and colorectal cancer.Semantic proximity Read ↗

Exome sequencing identifies highly recurrent MED12 somatic mutations in breast fibroadenoma.Semantic proximity Read ↗

Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.Semantic proximity Read ↗

MED12 mutations in leiomyosarcoma and extrauterine leiomyoma.Semantic proximity Read ↗

Frequency of MED12 Mutation in Relation to Tumor and Patient's Clinical Characteristics: a Meta-analysis.Semantic proximity Read ↗

MED12 and uterine smooth muscle oncogenesis: State of the art and perspectives.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.