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Article

The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.

Reproductive sciences (Thousand Oaks, Calif.) - 1 Feb 2024

Amendola Isabela Landsteiner Sampaio, Spann Marcus, Segars James, Singh Bhuchitra

Abstract excerpt

Uterine leiomyomas are the most common tumor of reproductive-age women worldwide. Although benign, uterine fibroids cause significant morbidity and adversely impact the quality of life for affected women. Somatic mutations in the exon 2 of the mediator complex subunit 12 (MED-12) gene represent the most common single gene mutation associated with uterine leiomyomas. The objective of this review was to evaluate...

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PMID: 37516697
DOI: 10.1007/s43032-023-01297-7

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The Mediator Complex Subunit 12 (MED-12) Gene and Uterine Fibroids: a Systematic Review.PMID 37516697Read ↗

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Whole exome sequencing in a random sample of North American women with leiomyomas identifies MED12 mutations in majority of uterine leiomyomas.Semantic proximity Read ↗

MED12 mutation frequency in unselected sporadic uterine leiomyomas.Semantic proximity Read ↗

Med12 gain-of-function mutation causes leiomyomas and genomic instabilitySemantic proximity Read ↗

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Mutations in Exon 1 highlight the role of MED12 in uterine leiomyomas.Semantic proximity Read ↗

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