Article
MED12 mutation activates the tryptophan/kynurenine/AHR pathway to promote growth of uterine leiomyomas.
JCI insight - 22 Sept 2023
Zuberi Azna, Huang Yongchao, Dotts Ariel J, Wei Helen, Coon John S, Liu Shimeng, Iizuka Takashi, Wu Olivia, Sotos Olivia, Saini Priyanka, Chakravarti Debabrata, Boyer Thomas G, Dai Yang, Bulun Serdar E, Yin Ping
Abstract excerpt
Uterine leiomyomas cause heavy menstrual bleeding, anemia, and pregnancy loss in millions of women worldwide. Driver mutations in the transcriptional mediator complex subunit 12 (MED12) gene in uterine myometrial cells initiate 70% of leiomyomas that grow in a progesterone-dependent manner. We showed a distinct chromatin occupancy landscape of MED12 in mutant MED12 (mut-MED12) versus WT-MED12 leiomyomas....
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