TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.

doi:10.1016/j.immuni.2021.12.007

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Article

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.

Immunity - 11 Jan 2022

Chaurio Ricardo A, Anadon Carmen M, Lee Costich Tara, Payne Kyle K, Biswas Subir, Harro Carly M, Moran Carlos, Ortiz Antonio C, Cortina Carla, Rigolizzo Kristen E, Sprenger Kimberly B, Mine Jessica A, Innamarato Patrick, Mandal Gunjan, Powers John J, Martin Alexandra, Wang Zhitao, Mehta Sumit, Perez Bradford A, Li Roger, Robinson John, Kroeger Jodi L, Curiel Tyler J, Yu Xiaoqing, Rodriguez Paulo C, Conejo-Garcia Jose R

Abstract excerpt

The immune checkpoint receptor PD-1 on T follicular helper (Tfh) cells promotes Tfh:B cell interactions and appropriate positioning within tissues. Here, we examined the impact of regulation of PD-1 expression by the genomic organizer SATB1 on Tfh cell differentiation. Vaccination of CD4CreSatb1f/f mice enriched for antigen-specific Tfh cells, and TGF-β-mediated repression of SATB1 enhanced Tfh differentiation of...

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PMID: 35021053
DOI: 10.1016/j.immuni.2021.12.007
PMCID: PMC8852221

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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