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Article

Spatial and phenotypic plasticity of B cells in remodeling the tumor microenvironment.

Journal for immunotherapy of cancer - 27 Mar 2026

Gao Yan, Peng Yinghui, Chen Yihong, Zeng Shan, Shen Hong, Martin Alberto, Cai Changjing, Han Ying

Abstract excerpt

While cancer immunotherapy has traditionally centered on T cells, accumulating evidence highlights the dual roles of tumor-infiltrating B lymphocytes (TIL-Bs) in both promoting and restraining tumor progression. Within tertiary lymphoid structures (TLSs), TIL-Bs undergo germinal center (GC) maturation and generate tumor-reactive antibodies that enhance antitumor T-cell immunity. However, in defined spatial,...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 41895712
DOI: 10.1136/jitc-2025-014745
PMCID: PMC13034221

Genes

CD4
GC

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026.

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