Article

Follicular helper T cells expressing Blimp1 are specialized for plasma cell differentiation

2022-04-01

Abstract excerpt

B cells differentiate into antibody-producing plasma cells (PC) and germinal center (GC) B cells under the guidance of specialized CD4 + follicular helper T (T FH ) cells. Here, we demonstrate that CD4 T cells require Prdm1 expression for both early PC differentiation and post-GC PC formation. Using dual Blimp1/Foxp3 reporter mice and single cell-indexed analysis, we segregate persistent compartments and expres...

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Literature Corpus work: 5f7fd099-a2c0-5429-a2d6-ed6f88dd49ab
DOI: 10.1101/2022.03.31.486642

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