Article

B-cells Drive Response to PD-1 Blockade in Glioblastoma Upon Neutralization of TGFβ-mediated Immunosuppression

2023-01-09

Abstract excerpt

<title>Abstract</title> <p>Immunotherapy has revolutionized cancer treatment but has yet to be translated into brain tumors. Studies in other solid tumors suggest a central role of B-cell immunity in driving immune-checkpoint-blockade efficacy. Using single-cell and single-nuclei transcriptomics of human glioblastoma and melanoma brain metastasis, we found that tumor-associated B-cells have high expression of che...

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Literature Corpus work: ec9c1bd8-7c6d-569f-b5ef-34604d1700a7
DOI: 10.21203/rs.3.rs-2399170/v1

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