Article

SATB1 is a targetable modulator of JAK-STAT signaling and cytokines in human Treg and Tconv cells

2026-02-16

Abstract excerpt

<h4>ABSTRACT</h4> The chromatin organizer SATB1 is indispensable for thymic regulatory T cell (Treg cell) development and T helper cell induction. Several gene loci have been described to be SATB1-controlled, including the transcription factor GATA3 and the cytokine loci IL-4 and IL-17. However, the global effects of SATB1 on fully differentiated human CD4 conventional T cells (Tconv cells) and Treg cells, and th...

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Literature Corpus work: b6037739-37de-5bb6-8de5-6d5c250b194a
DOI: 10.64898/2026.02.13.705474

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