Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer.

doi:10.1038/s41467-024-46873-w

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Article

Tertiary lymphoid structures and B cells determine clinically relevant T cell phenotypes in ovarian cancer.

Nature communications - 21 Mar 2024

Kasikova Lenka, Rakova Jana, Hensler Michal, Lanickova Tereza, Tomankova Jana, Pasulka Josef, Drozenova Jana, Mojzisova Katerina, Fialova Anna, Vosahlikova Sarka, Laco Jan, Ryska Ales, Dundr Pavel, Kocian Roman, Brtnicky Tomas, Skapa Petr, Capkova Linda, Kovar Marek, Prochazka Jan, Praznovec Ivan, Koblizek Vladimir, Taskova Alice, Tanaka Hisashi, Lischke Robert, Mendez Fernando Casas, Vachtenheim Jiri, Heinzelmann-Schwarz Viola, Jacob Francis, McNeish Iain A, Halaska Michal J, Rob Lukas, Cibula David, Orsulic Sandra, Galluzzi Lorenzo, Spisek Radek, Fucikova Jitka

Abstract excerpt

Intratumoral tertiary lymphoid structures (TLSs) have been associated with improved outcome in various cohorts of patients with cancer, reflecting their contribution to the development of tumor-targeting immunity. Here, we demonstrate that high-grade serous ovarian carcinoma (HGSOC) contains distinct immune aggregates with varying degrees of organization and maturation. Specifically, mature TLSs (mTLS) as forming...

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Identifiers

PMID: 38514660
DOI: 10.1038/s41467-024-46873-w
PMCID: PMC10957872

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