B cells spatial organization defines their phenotype and function in cancer "Tell me with whom you consort, and I will tell you who you are" - Goethe.

Abstract excerpt

The presence of B cells and their subtypes in the tumor environment has been recognized a for very long time. Immunoglobulins specific for more than thousands of tumor-associated antigens were detected in the sera of patients with cancer; however, antibody-mediated cancer cell killing is usually impaired. The role of humoral immune response remained elusive until recently, with new discoveries regarding their...

Topics

• Humans
• Tumor Microenvironment
• Neoplasms
• Animals
• B-Lymphocytes
• Phenotype
• Immunity, Humoral
• Lymph Nodes
• Immunotherapy