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Article

Divergent SATB 1 expression across human life span and tissue compartments

25 Feb 2019

Abstract excerpt

Abstract Special AT‐rich binding protein‐1 (SATB1) is a global chromatin organizer capable of activating or repressing gene transcription in mice and humans. The role of SATB1 is pivotal for T‐cell development, with SATB1‐knockout mice being neonatally lethal, although the exact mechanism is unknown. Moreover, SATB1 is dysregulated in T‐cell lymphoma and proposed to suppress transcription of the Pdcd1 gene,...

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Identifiers

PMID: 30803026
DOI: 10.1111/imcb.12233

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