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Article

Satb1 directs the differentiation of TH17 cells through suppression of IL-2 expression

17 Jun 2025

Abstract excerpt

T helper (T H )17 cells are crucial for host defense in barrier organs, and their altered functionality can disrupt tissue homeostasis, increasing the risk of autoimmune diseases. Thus, it is essential to understand the mechanisms controlling T H 17 differentiation to develop strategies influencing their role in diseases. Here, we identified Special AT-rich sequence-binding protein 1 (Satb1) as a pioneering...

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PMID: 40531625
DOI: 10.1016/j.celrep.2025.115866

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