Article

TGF-β induced CXCL13 in CD8+ T cells is associated with tertiary lymphoid structures in cancer

2018-04-18

Abstract excerpt

Coordinated immune responses against human tumors are frequently characterized by tertiary lymphoid structures (TLS) which predict improved prognosis. The development of TLS is dependent on the chemokine CXCL13, reported to be secreted by dendritic cells and follicular helper T cells only. We report the unexpected finding that CXCL13 is also secreted by activated CD8+ T cells following stimulation by transforming...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 81b15b23-4278-5522-a041-b43161f52049
DOI: 10.1101/303834

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

TGF-β induced CXCL13 in CD8+ T cells is associated with tertiary lymphoid structures in cancerDOI 10.1101/303834Read

Tertiary lymphoid structures induced by CXCL13-producing CD4 <sup>+</sup> T cells increase tumor infiltrating CD8 <sup>+</sup> T cells and B cells in ovarian cancerSemantic proximity Read

Cellular and molecular events organizing the assembly of tertiary lymphoid structures in glioblastomaSemantic proximity Read

Active secretion of CXCL10 and CCL5 from colorectal cancer microenvironments associates with GranzymeB+ CD8+ T-cell infiltration.Semantic proximity Read

Intratumoral CD103+ CD8+ T cells predict response to PD-L1 blockade.Semantic proximity Read

Phenotypic Characterization and Prognostic Impact of CD103+ Tissue-Resident Memory T Cells in Diffuse Large B-cell Lymphoma.Semantic proximity Read

Tumor-Associated Tertiary Lymphoid Structures: Gene-Expression Profiling and Their BioengineeringSemantic proximity Read

CXCL9 and CXCL13 coordinately shape the immune-activated microenvironment of endometrial cancer via tertiary lymphoid structure formationSemantic proximity Read

CXCL13-CXCR5 Signaling in CD8⁺ T Cell Recruitment and Lymphoid Immune Organization in Clear Cell Renal Cell CarcinomaSemantic proximity Read

Self-Maintaining CD103+ Cancer-Specific T Cells Are Highly Energetic with Rapid Cytotoxic and Effector ResponsesSemantic proximity Read

Epigenetic targets to enhance antitumor immune response through the induction of tertiary lymphoid structuresSemantic proximity Read

TGF-β-mediated silencing of genomic organizer SATB1 promotes Tfh cell differentiation and formation of intra-tumoral tertiary lymphoid structures.Semantic proximity Read

CD103+ intraepithelial T cells in high-grade serous ovarian cancer are phenotypically diverse TCRαβ+ CD8αβ+ T cells that can be targeted for cancer immunotherapy.Semantic proximity Read