Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

TFH cells progressively differentiate to regulate the germinal center response.

Nature immunology - 1 Oct 2016

Weinstein Jason S, Herman Edward I, Lainez Begoña, Licona-Limón Paula, Esplugues Enric, Flavell Richard, Craft Joe

Abstract excerpt

Germinal center (GC) B cells undergo affinity selection, which depends on interactions with CD4(+) follicular helper T cells (TFH cells). We found that TFH cells progressed through transcriptionally and functionally distinct stages and provided differential signals for GC regulation. They initially localized proximally to mutating B cells, secreted interleukin 21 (IL-21), induced expression of the transcription...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Antibody Affinity
Share to CD4 Antigens

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Germinal Center

Share to Interleukin-21

Share to Interleukin-4

Share to Positive Regulatory Domain I-Binding Factor 1

Share to Strongylida Infections

Share to T-Lymphocytes, Helper-Inducer

Source

Open in PubMed Open full text

Identifiers

PMID: 27573866
DOI: 10.1038/ni.3554
PMCID: PMC5030190

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

TFH cells progressively differentiate to regulate the germinal center response.PMID 27573866Read ↗

Germinal center B cell and T follicular helper cell development initiates in the interfollicular zone.Semantic proximity Read ↗

The elusive identity of T follicular helper cells.Semantic proximity Read ↗

Molecular Control of Follicular Helper T cell Development and DifferentiationSemantic proximity Read ↗

Functional differentiation and regulation of follicular T helper cells in inflammation and autoimmunity.Semantic proximity Read ↗

Transcription factor achaete-scute homologue 2 initiates follicular T-helper-cell development.Semantic proximity Read ↗

Minimalistic In Vitro Culture to Drive Human Naive B Cell Differentiation into Antibody-Secreting CellsSemantic proximity Read ↗

Signals that drive T follicular helper cell formation.Semantic proximity Read ↗

T follicular helper cells in germinal center B cell selection and lymphomagenesis.Semantic proximity Read ↗

Bcl6 protein expression shapes pre-germinal center B cell dynamics and follicular helper T cell heterogeneity.Semantic proximity Read ↗

BCL6 orchestrates Tfh cell differentiation via multiple distinct mechanismsSemantic proximity Read ↗

T‐follicular helper cell differentiation and the co‐option of this pathway by non‐helper cellsSemantic proximity Read ↗

The germinal center: a crucible for lymphocyte selection.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.