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B Cells and Tertiary Lymphoid Structures: Friends or Foes in Cancer Immunotherapy?

28 Dec 2021

Abstract excerpt

Tumor cells pose a challenge to the adaptive immune system, and its key cell types, T and B cells, have frequently been associated with an improved prognosis. The success of immune checkpoint blockade has confirmed the relevance of T cells. However, the role of B cells is increasingly recognized, and highlighted in this review. Recent data suggest that tumors contain a diverse set of B cells reflecting different...

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PMID: 34965949
DOI: 10.1158/1078-0432.ccr-21-1130

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